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DHEA Augmentation of Musculoskeletal Adaptations to Exercise in Older Women

Study category: Bones, Muscles, and Joints

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If you join the study, you will be placed by chance into one of two research groups: 1) exercise and a study pill or 2) no exercise and a study pill. The study pill could be DHEA (50 mg/day) or a placebo. A placebo is a pill that looks like medicine but is not real. DHEA is a naturally occurring hormone that declines with age. In postmenopausal women, nearly all estrogen and most testosterone comes from DHEA. DHEA is considered a food supplement.




Women, 60-85 years of age; not using sex hormone replacement (like estrogen); not exercising regularly; have low bone mass (osteopenia); willing to attend exercise sessions 3 days per week in the Exercise Research Lab on the Anschutz Medical Campus; planning to remain in the greater Denver area for the next 12 months.

no history of hormone sensitive cancer (for example, breast cancer); nonsmoking

Type of Study

Outcomes Research


Outpatient CTRC
University of Colorado Hospital

Principal Investigator
Catherine Jankowski,  PhD

Catherine Jankowski, PhD

Study ID

Protocol Number: 16-2427

More information available at NCT03227458

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