Inhaled Cannabis, Oxidative Stress and the Pulmonary Innate Immune Response
Primary Objective
We are looking for people aged 25 to 55 who smoke and/or vape cannabis, and people aged 25 to 55 who do not smoke cannabis, to see how cannabis use affects lung health over time.

Description
This study compares the lung health of people who do not smoke cannabis to the lung health of people who have smoked cannabis for a long time.
Main Procedures Involved: If you join this study, you will have one visit that lasts about 4-5 hours at UC Health. During the visit, the study doctor will perform a bronchoscopy, which is a procedure that allows us to look at your lungs using a small scope. This procedure is low risk and safe. During the procedure, we will give you medicines to help you relax. You will still be awake and be able to hear and communicate using your hands. This is called conscious sedation.
You will also get a chest x-ray, lung function test (spirometry), blood draw, nasal brushings, and give urine and stool samples, and you will fill out online surveys.
Duration of Participation: One 4-5 hour visit on a weekday morning
Details
1) Smoke cannabis every day or almost every day
2) Never or very rarely use tobacco products
3) Have no long-term lung, heart, liver, or kidney problems
If you do not use any cannabis products, you may join this study if you:
1) Have never smoked cannabis or used cannabis products
2) Have no long-term lung, heart, liver, or kidney problems
This is a shortened list. There are other criteria the study team will talk to you about during the screening process.
Locations
CTRC Inpatient
University of Colorado Hospital
Principal Investigator

Ellen Burnham
Study ID
Protocol Number: 14-1957
Categories
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