Zoster Eye Disease Study (ZEDS): A multi-center, randomized, double-masked, placebo-controlled clinical trial of suppressive valacyclovir for one year in immunocompetent study participants with an episode of dendriform epithelial keratitis, stromal keratitis, endothelial keratitis, and/or iritis due to Herpes Zoster Ophthalmicus (HZO) in the year prior to enrollment
This Study is
No Longer Enrolling
This study is looking to see if treatment with 12 months of daily valacyclovir medication reduces the development of certain types of new or worsening eye disease; specifically, infection on the surface of the front of the eye (cornea), inflammation of the cornea, or inflammation inside the front of the eye. We also hope to find out if this treatment reduces ongoing pain after the shingles infection goes away. In addition, we want to find out if the effects of valacyclovir treatment last during the six months after treatment is finished.
MoreAdult
Patient must be diagnosed with shingles in one eye (Herpes Zoster Ophthalmicus), be willing to comply with all study procedures and take oral medication, and to adhere to study medication regimen. If you are immunocompromised or have a history of certain medical conditions, this might exclude you from participation in this study.
Treatment
University of Colorado Hospital
Protocol Number: 17-0585
More information available at ClinicalTrials.gov: NCT03134196
Not finding the right Study for you? Join ResearchMatch, a nation-wide registry connecting volunteers and researchers