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Tissue-specific effects of insufficient sleep

Study category: Diabetes & Hormone Disorders

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Description

The proposed project is a within-subject consecutive design examining 14 healthy individuals after baseline and after 4 nights of insufficient sleep. Following 7 days of at-home habitual sleep of 9 hours/night and a 3-day lead-in energy balanced diet, participants will be admitted for a 6-night inpatient stay at the UC Denver. Sleep schedules will be verified via sleep logs, time-stamped voice-recorder of bed and wake times, and wrist actigraphy recordings. On the morning after the 1st night in the lab, subjects will undergo including saliva sampling, endothelial function testing, muscle biopsy, fat biopsy, hyperinsulinemic euglycemic clamp.

Details
Age

Adult

Eligibility

1) 18-35 years old; men and women 2) Physical activity history: no regular physical activity (<20 minutes/day ? self report). Exercise will be proscribed for 3 days prior to study start. 3) Sleep/wake history: habitual sleep duration between 7-9.25h (determined by self-report during interview). a. During the screening process, subjects are asked questions about their present, past habitual sleep/wake schedule and nap times. Participants will be included if habitual sleep duration is > 7 and < 9.25h. We screen potential subjects who sleep < 7 or > 9.25h per night since there are significant medical and psychological disorders that are commonly associated with more extreme habitual sleep durations (e.g., depression, thyroid disease, sleep disorders, alcoholism). b. Subjects must be willing to maintain a 7 day consistent self-selected ~9h sleep schedule, which will be verified by wrist actigraphy, sleep logs, and either call-ins to a time stamped recorder or completing a secure, web-based survey program. 4) Altitude history: Potential subjects must have lived at Denver altitude or higher for at least 3 months to inpatient study to control for physiological adjustment to altitude (self-report by interview). 5) The subject must be able to read and understand the consent form and provide written informed consent, indicating the subject?s understanding of the purpose of the study and willingness to perform procedures described in the protocol. Our performance tests are in English and thus knowledge of English is a requirement.

Type of Study

Basic Science

Locations

CTRC Inpatient
CTRC-UC Boulder
University of Colorado Hospital

Principal Investigator
Josiane Broussard,  PhD

Josiane Broussard, PhD

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