Cardiovascular Mechanisms of Exercise Intolerance in Diabetes and the Role of Sex

Primary Objective

This study will define the relationship of cardiac, vascular function and skeletal muscle blood flow (individually and together) to cardiovascular exercise capacity in in men and women with and without type 2 diabetes (T2DM). Identification of differences in the effects of exercise training on the integrated cardiovascular system and metabolism in men and women with and without T2DM will reveal specific adaptive responses to exercise. This study will evaluate & compare exercise function in a total of 60 subjects from the Denver area (30 people with T2DM and 30 overweight control subjects).

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Participants will undergo baseline testing of heart and blood vessel function as well as skeletal muscle function and exercise ability. Participants will then do cardiovascular exercise for 15 weeks, and all testing will be repeated.

Main Procedures Involved: Testing includes cardiac ultrasound, exercising on a stationary bicycle, tests of insulin sensitivity, muscle biopsy, and MRI.

Duration of Participation: Total duration of participation will last approximately 6 months.


30 to 55 years


Age 30-55 BMI 25-40 Women must be pre-menopausal With or without type 2 diabetes A1C <5.7% for controls and <9% for those with diabetes

Participants with diabetes cannot be taking insulin Participants cannot have any cardiovascular disease or physical impairments that limit ability to exercise on a stationary bicycle.

Type of Study

Outcomes Research





Principal Investigator
Photograph of Jane Reusch,  MD

Jane Reusch, MD

Study ID

Protocol Number: 17-0356

More information available at NCT03419195

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