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Cardiovascular Mechanisms of Exercise Intolerance in Diabetes and the Role of Sex

Primary Objective

This study will define the relationship of cardiac, vascular function and skeletal muscle blood flow (individually and together) to cardiovascular exercise capacity in in men and women with and without type 2 diabetes (T2DM). Identification of differences in the effects of exercise training on the integrated cardiovascular system and metabolism in men and women with and without T2DM will reveal specific adaptive responses to exercise. This study will evaluate & compare exercise function in a total of 60 subjects from the Denver area (30 people with T2DM and 30 overweight control subjects).

Study category: Diabetes & Hormone Disorders

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Men and women ages 30-55 with type 2 diabetes OR men and women ages 30-55 without type 2 diabetes.


Not Applicable - Describes studies without FDA-defined phases, including studies of devices or behavioral interventions.

Type of Study

Outcomes Research




University of Colorado Hospital

Principal Investigator
Jane Reusch,  MD

Jane Reusch, MD

Study ID

Protocol Number: 17-0356

More information available at NCT03419195

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