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Measurement of Hematopoietic Stem Cell Derived Adipocytes

Primary Objective

To understand if some fat cells (adipocytes) may originally come from cells in the bone marrow. Understanding the origin of fat cells is important because it may help to determine the health of fat cells and why fat that is stored in some places of your body is more unhealthy than other fat.

Study category: Heart and Blood Conditions

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Description

The purpose of this study is to learn more about where the fat tissue in your body originates. For many years it has been thought that all fat cells come from cells that are from the fat tissue itself, but now we know it is possible that some fat cells may originally come from the bone marrow. Understanding the origin of fat cells is important because it may help to determine the health of fat cells. You are being asked to be in this research study because you are a person over the age of 18 who has had a hematopoietic stem cell transplant or has chronic phase chronic myeloid leukemia (CML).

Details
Age

Adult

Eligibility

Aims 1 & 2: Participants, aged 18 -75. will have a history of allogeneic hematopoietic stem cell transplantation (>180 days post-transplant). Participants may be on minimal calcineurin inhibitors (cyclosporine < 100 mg BID or tacrolimus < 1mg BID). Aims 2 & 3: Participants, aged 18-75, will have chronic phase chronic myeloid leukemia (CML).

Detailed Eligibility: Aims 1 & 2: Participants, aged 18 -75. will have a history of allogeneic hematopoietic stem cell transplantation (>180 days post-transplant). Participants may be on minimal calcineurin inhibitors (cyclosporine < 100 mg BID or tacrolimus < 1mg BID). Aims 2 & 3: Participants, aged 18-75, will have chronic phase chronic myeloid leukemia (CML).

Type of Study

Basic Science

Location

University of Colorado Hospital

Principal Investigator
Dwight Klemm

Dwight Klemm

Study ID

Protocol Number: 13-0026

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