Participate in Research at CU Anschutz

Adult

Inclusion: Age 18-49 years (1) T1D diagnosis defined as positive T1D-associated antibody(ies) or (2) a clinical diagnosis of T1D plus insulin Insulin pump or automated insulin delivery systems requirement since diagnosis eGFR ≥ 45 ml/min/1.73m2 Adequate contraceptive method for females Stable doses of drugs altering cardiovascular and renal function (e.g., ACEi, ARB, statins, diuretics) BMI 20-45 kg/m2 Exclusion: HbA1c >9%, recent DKA or hospitalization Major congenital heart disease, anemia, severe non-proliferative retinopathy, proliferative retinopathy History/family history of medullary thyroid carcinoma, MEN2, pancreatitis Current/planned pregnancy or nursing Uncontrolled thyroid disease or hypertension (≥ 160/100 mm Hg despite optimal therapy) Use of other non-insulin diabetes medications, insulin sensitizing medications, or systemic steroids in past 3 months Use of atypical antipsychotics Shellfish/iodine allergy (only exclusionary to iohexol clearance procedure) Significant systemic illness such as cancer MRI or PAH contraindications (only exclusionary to MRI and PAH procedures), GLP-1RA allergy