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The impact of estrogen status on the biological function of brown adipose tissue in women measured using quantitative PET/CT

Study category: Healthy Volunteers

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The physiological relevance of brown adipose tissue in humans is largely unknown. We have shown that suppressing ovarian function in premenopausal women reduces resting energy expenditure (REE), and this is prevented by adding back estradiol (E2). Our preliminary data suggest that this may be due, in part, to reduced brown adipose tissue (BAT) activity. However, whether E2 status affects BAT activity in women has not been studied. In this research, we will study 1) the contribution of BAT to REE under basal (room temperature) and stimulated conditions (mild cold-exposure); and 2) whether these responses are modulated by E2 status.




Premenopausal volunteers will be healthy, normal cycling women, aged 18-50 yrs. Postmenopausal volunteers will be healthy women who have no menses for at least 12 months.

Detailed Eligibility: Additional exclusion criteria for postmenopausal women o History or current use of hormonal replacement therapy o Women who have undergone surgical menopause. ?Additional exclusion criteria for premenopausal women o Current hormonal contraceptive use (past 6 mo). o Pregnant, lactating or intention to become pregnant during the period of study


Not Applicable - Describes studies without FDA-defined phases, including studies of devices or behavioral interventions.

Type of Study

Basic Science




University of Colorado Hospital

Principal Investigator
Ed Melanson

Ed Melanson

Study ID

Protocol Number: 16-1479 NCT02927392

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