University of Colorado Alzheimer's and Cognition Center Longitudinal Biomarker and Clinical Phenotyping Study (Bio-AD Study)

Primary Objective

Research Study to Help us Better Understand Alzheimer’s Disease, Down Syndrome, and Other Types of Thinking/Memory Problems

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This study will establish a large bank of samples and data for future research into the causes of and treatments for Alzheimer’s disease (AD), Down Syndrome (DS) and other diseases that cause thinking and memory problems.

Main Procedures Involved: Once a year (that takes about 4-5 hours): • Physical/neurological exam • Set of tests that assess memory, attention, behavior, and other thinking skills • Questionnaires about health history • Collection of blood sample • Questionnaires to be completed by a study partner (a family member or close friend) • Review of medical records and collection of information about general health and thinking/memory issues • MRI of the brain (optional for DS participants) • Be considered for other studies at the University of Colorado Alzheimer’s and Cognition Center Lumbar puncture is optional for all participants. If a 4-5 hour visit feels too overwhelming, the study team offers to cover the same procedures in two shorter visits.

Duration of Participation: As long as possible



Type of Study


Principal Investigator
Photograph of Brianne Bettcher,  PhD

Brianne Bettcher, PhD

Study ID

Protocol Number: 15-1774

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