Real-Time Assessment of Lung Structure and Function in Children and Young Adults with CF using Electrical Impedance Tomography

Primary Objective

1. Design and validate an improved, novel-design, high performance EIT system to meet the enhanced imaging demands of the present study. 2. Develop 3-D algorithms to compute regional aeration and ventilation perfusion ratio (V/Q) maps in 3-D, and to identify and quantify regions of air trapping and consolidation. Extend existing algorithms for EIT-derived measures of PFTs and coefficients of spatial variation to 3-D. 3. Determine the ability of EIT to identify structural and functional physiological changes that occur with disease progression.

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Single visit to Children's Hospital Colorado - During this visit your height, weight, date of birth, and gender will be recorded. You will also have some tests done including pulmonary function testing (spirometry), EIT, and multiple breath washout (MBW).


Child to Adult


Healthy controls (no evidence of chronic or temporary pulmonary disease) 3-18 years old

Type of Study

Device Feasibility




Childrens Hospital Colorado

Principal Investigator
Photograph of Jordana Hoppe,  MD

Jordana Hoppe, MD

Study ID

Protocol Number: 22-0114

More information available at NCT05455671

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