Study | Research Studies | School of Medicine

Protocol 24-1819 (Thermogenic responses to fasting and overfeeding in women: a potential mechanism contributing to postmenopausal weight gain)

Primary Objective

Compare the change in 24-h EE in response to acute fasting in pre- and postmenopausal women. Compare the change in 24-h EE in pre- and postmenopausal women in response to acute low-protein overfeeding (200% of energy balance).

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Description

During and after menopause, women are prone to increased weight gain. The increase in weight and body fat with menopause may be due to changes in metabolism related to the loss of estrogen. This research study plans to compare how the metabolism of premenopausal and postmenopausal women responds to over and underfeeding.

Details

Age

Adult

Eligibility

Premenopausal - healthy, eumenorrheic women, aged 18-45 yrs. Postmenopausal volunteers will be healthy women aged 45-65 years who have no menses for at least 12 monthsPremenopausal - healthy, eumenorrheic women, aged 18-45 yrs. Eumenorrheic status will be verified by regular menses (no missed cycles in the previous year; cycle length 25-35 d). Postmenopausal volunteers will be healthy women aged 45-65 years who have no menses for at least 12 months; postmenopausal status will be confirmed based on FSH (>49.9 mIU/ml).

Locations

CTRC Inpatient
Outpatient CTRC
University of Colorado Hospital

Principal Investigator

Ed Melanson

Study ID

Protocol Number: 24-1819

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