Age
Adult
Eligibility
- Age 18-55 years
- Body Mass Index 25-40 kg/m2
- <100 minutes per week of exercise at moderate intensity or greater and <60 min per day of total habitual physical activity (i.e., work related, transportation related) at moderate intensity or greater, over the past 3 months.
- No acute or chronic disease (cardiovascular disease (CVD), diabetes, pulmonary, gastrointestinal disorders, and orthopedic problems in particular).
- No plans to relocate within the next 12 months.
- No plans for extended travel (>2 weeks) within the next 12 months.
- Live or work within 20 miles of the Anschutz Medical Campus
- For Females: Not currently pregnant or lactating, Not pregnant within the past 6 months, Not planning to become pregnant in the next 12 months. Inclusion Criteria:
- Age 18-55 years
- Body Mass Index 25-40 kg/m2
- <100 minutes per week of exercise at moderate intensity or greater and <60 min per day of total habitual physical activity (i.e., work related, transportation related) at moderate intensity or greater, over the past 3 months.
- No self-report of acute or chronic disease
- No plans to relocate within the next 12 months.
- No plans for extended travel (>2 weeks) within the next 12 months.
- Live or work within 20 miles of the AHWC
- Capable and willing to give informed consent, understand exclusion criteria, and accept the randomized group assignment.
- Have a primary care physician (or are willing to establish care prior to study enrollment)
No contraindications to exercise or limitations on ability to be physically active.
- Agree to refrain from use of obesity pharmacotherapeutic agents during the 6 month pilot study.
- Females: Not currently pregnant or lactating, Not pregnant within the past 6 months, Not planning to become pregnant in the next 12 months. Sexually active women of childbearing potential may be enrolled if they have had a tubal ligation or use a reliable means of contraception.
Exclusion Criteria:
- Diastolic blood pressure >100 mmHG, systolic blood pressure >160 mmHG, or resting heart rate >100 bpm
- Diabetes
- Undiagnosed hypo- or hyper-thyroid or history of uncontrolled thyroid disorder.
- Hematocrit, white blood cell count or platelets significantly outside the normal reference range
- Triglycerides >400 mg/dL
- LDL cholesterol >200 mg/dL
- Abnormal resting electrocardiogram
- Presence or history of CVD, peripheral vascular disease, cerebrovascular disease, significant cardiac arrhythmias or cardiac valve disease, diabetes, uncontrolled hyper- or hypothyroidism, uncontrolled hypertension, cancer, HIV infection, significant gastrointestinal disorders, significant pulmonary disorders, significant renal, musculoskeletal, neurologic, hematologic, or psychiatric disease.
- Significant gastrointestinal disorders including chronic malabsorptive conditions, active peptic ulcer disease, Crohns disease, Ulcerative Colitis, chronic diarrhea, or active gallbladder disease.
- Chronic obstructive pulmonary disease (COPD), interstitial lung disease, cystic fibrosis, or uncontrolled asthma.
- Chest pain, shortness of breath at rest or with mild exertion, syncope.
- Primary sleep disorders including but not limited to insomnia, moderate or greater severity obstructive sleep apnea, periodic limb movements in sleep, restless leg syndrome.
- Night-time shiftwork, rotating work, or other circadian disruptions and disorders
- Regular use of prescription or over-the-counter medications known to affect sleep
- Regular use of melatonin (greater than or equal to 2 days per week).
- Regular use of prescription or over-the-counter medications known to affect appetite, weight, or energy metabolism
- Regular use of systemic glucocorticoids.
- Regular use of obesity pharmacotherapeutic agents within the last 6 months.
- Previous obesity treatment with surgery or weight loss device
- Current alcohol or substance abuse.
- Nicotine use (current or quit in the past 6 months).
- History of clinically diagnosed eating disorders including anorexia nervosa, bulimia, binge eating disorder.
- Current severe depression or history of severe depression within the previous year
- History of other significant psychiatric illness (e.g., psychosis, schizophrenia, mania, bipolar disorder)
- Currently participating in or planning to participate in any formal weight loss programs, physical activity programs, or clinical trials.
- Weight change ± 5 kg in past 3 months.
