Effect of GLP-1 Agonist Therapy on Insulin Secretion in Adults with Pancreatic Insufficient Cystic Fibrosis and Abnormal Glucose Tolerance: a randomized, open-label, cross-over trial

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This research is being done to better understand Cystic-Fibrosis Related Diabetes (CFRD) and to see the effects of GLP-1 (dulaglutide) in individuals with abnormal glucose tolerance. GLP-1 (dulaglutide) helps the pancreas release insulin, which controls blood sugar levels from getting too high and is currently prescribed to people with Type 2 diabetes. We are looking at how GLP-1 (dulaglutide) might help improve blood sugar levels for people with CF and abnormal glucose tolerance..




Male or female, aged 18 or older at time of consent; confirmed diagnosis of CF; pancreatic insufficiency; and abnormal glucose tolerance.Stated willingness to comply with all study procedures and availability for the duration of the study; ability to take subcutaneous medication and be willing to adhere to the weekly administration regimen and complete study specific procedures (MMTT-mixed meal tolerance test); for females of reproductive potential: use of highly effective contraception for at least 1 month prior to screening and agreement to use such a method during study participation and for an additional 6 weeks after the end of dulaglutide or observation...


Childrens Hospital Colorado

Principal Investigator
Photograph of Christine Chan

Christine Chan

Study ID

Protocol Number: 23-1267

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