Participate in Research at CU Anschutz

Adult

(1) Age 21-65 years inclusive; (2) Meets DSM-5 criteria for past-year moderate or severe methamphetamine use disorder; (3) At least 10 days of methamphetamine use out of the last month; (4) Provides a urine drug screen positive for methamphetamine; (5) Able to provide informed consent; (6) No change in current psychiatric medication regimen, or medication free, for at least 4 weeks prior to study entry.Inclusion Criteria: (1) Age 21-65 years inclusive; (2) Meets DSM-5 criteria for past-year moderate or severe methamphetamine use disorder; (3) By Timeline Follow Back endorses at least 10 days of methamphetamine use out of the last month; (4) Provides a urine drug screen positive for methamphetamine; (5) Able to provide informed consent; (6) No change in current psychiatric medication regimen, or medication free, for at least 4 weeks prior to study entry. Exclusion Criteria: (1) Lifetime non-substance-induced psychotic disorders, schizophrenia, schizoaffective disorder or bipolar disorder defined by DSM-5; (2) Current diagnosis of DSM-5 drug use disorder other than stimulant, cannabis or nicotine use disorder; (3) Non-substance-induced manic episode within the past 3 years or major depressive episode in the past year; (4) Current clinically significant neurological disorder or medical illness, including history of seizures, cardiovascular disease/cardiac event, which in the opinion of the study physician would make study participation unsafe; (5) Presence of a clinically significant abnormality on baseline MRI; (6) Inability to have an MRI; (7) Currently breastfeeding, is currently pregnant or lack of use of effective contraception in women of childbearing age, as assessed by urine pregnancy test and self-report (participants will consent to continue effective contraceptives during the study); (8) Active criminal justice involvement (i.e., any unresolved legal problems that could jeopardize continuation or completion of the study); (9) History of head injury with loss of consciousness for more than 15 minutes; (10) Diagnosis of dementia; (11) Prescribed benzodiazepines or anticonvulsants; (12) Currently enrolled in formal substance use disorder treatment; (13) Metal implants or non-removable metal objects above the waist; (14) Lifetime history of prior clinical treatment with TMS; (15) Serious risk of suicide or homicide; (16) Unable/unwilling to follow the study procedures; (17) History of intractable migraine; (18) Assessed to be at risk for alcohol or opioid withdrawal.