A Double-Blinded, Placebo-Controlled, Randomized, 2 Period, Crossover Phase 1/2a Study to Test the Safety and Efficacy of Advair HFA (Salmeterol and Fluticasone) in Resting and Exercising Healthy and High Altitude Pulmonary Edema (HAPE) Predisposed Subjects
The study involves two separate study periods of 12 days each, where you will: • Take the study drug or placebo through a puffer for 7 days. You will not know which drug you are taking during which period • Wear a continuous heart monitor for 12 days • Have blood tests drawn during 5 visits • Complete an exercise performance test while breathing air that has a low oxygen levels (similar to the air at high altitude)
MoreAdult
You may be eligible to participate if you: • Are 18-50 years old • Are generally in good health • Do not use any recreational drugs, tobacco, or vape products
Treatment
CTRC Inpatient
Outpatient CTRC
James Maloney, MD
Protocol Number: 23-0463
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