Phenotyping Resting and Exertional Right Ventricular Dysfunction Among Patients with Chronic Obstructive Pulmonary Disease and Pulmonary Artery Enlargement

Primary Objective

The primary objective of this proposal is to define phenotypes of resting and exertional right ventricular dysfunction among patients with chronic obstructive pulmonary disease (COPD) and pulmonary artery enlargement.

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Study participants will undergo testing to identify patterns of right ventricular dysfunction. If a study participant decides to participate in exercise training, the participant will complete an optional Part 2 of the study. Optional Part 2 includes an exercise training intervention followed by repeat testing to determine impact of exercise training on right ventricular dysfunction.




-COPD (determined by ratio of forced expiratory volume in 1 second to forced vital capacity [FEV1/FVC] <0.7) -Pulmonary artery enlargement determined by pulmonary artery-to-aorta ratio >1 or >30 mm obtained within 3 years of enrollment and not during an acute exacerbation of COPD


CTRC Inpatient
Outpatient CTRC
University of Colorado Hospital

Principal Investigator
Photograph of Lindsay Forbes

Lindsay Forbes

Study ID

Protocol Number: 23-0516

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