Participate in Research at CU Anschutz

We will investigate the association between transfusion of fibrinogen-containing blood products and multi-organ dysfunction resulting from endotheliopathy of trauma (EOT). Fibrinogen is frequently acutely decreased in critically ill trauma patients. Early fibrinogen replacement may be the key to restoring the endothelial glycocalyx and preventing end-organ injury. However, few human data exist to guide treatment.

Blood draws will be completed at baseline, 6-24 hours after arrival, and then daily through study day 7 to evaluate fibrinogen levels and response to trauma.