Effect of weight loss on intermuscular adipose tissue (IMAT) signaling
Primary Objective
The goal of this intervention study is to learn about how weight loss impacts molecular signaling of intermuscular adipose tissue (IMAT) in individuals with obesity. The main question it aims to answer is how inflammatory molecules secreted by IMAT promote muscle insulin resistance and inflammation, and how these same molecules are diminished after weight loss. Researchers will compare outcomes of individuals who lost weight to individuals who did not lose weight.
Description
Following screening visits involving body composition measures, blood testing, strength testing, and a thigh muscle biopsy, participants will go through a 12-week dietary intervention for weight loss. After 12 weeks, this will be followed by the same testing and biopsies that were completed before the intervention.
Details
Locations
Brain Imaging Center (BIC) - Scan Read
CTRC Inpatient
Outpatient CTRC
Principal Investigator
Bryan Bergman
Study ID
Protocol Number: 23-0545
Is this Study for You?
Not finding the right Study for you? Join ResearchMatch, a nation-wide registry connecting volunteers and researchers