Effect of weight loss on intermuscular adipose tissue (IMAT) signaling
Description
Following screening visits involving body composition measures, blood testing, strength testing, and a thigh muscle biopsy, participants will go through a 12-week dietary intervention for weight loss. After 12 weeks, this will be followed by the same testing and biopsies that were completed before the intervention.
Details
Age
18 to 70 years
Eligibility
Inclusion Criteria:
Generally healthy men and women aged 18-70
BMI between 30-40
Less than 1 hour of exercise per week
Women:
may be pre or post menopausal
Exclusion Criteria:
Type 1 or Type 2 diabetes
Thyroid disease
History of lung disease
Active use of nicotine
Severe plasma lipid disorders
Taking hormone replacement drugs, blood thinners, or thiazoladinediones
Women:
Currently going through menopause or peri-menopause
Pregnant or breastfeeding
History of Polycystic Ovary Syndrome
Compensation
compensation provided
Locations
Brain Imaging Center (BIC) - Scan Read
CTRC Inpatient
Outpatient CTRC
Principal Investigator
Bryan Bergman
Study ID
Protocol Number: 23-0545
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