Effect of weight loss on intermuscular adipose tissue (IMAT) signaling
Following screening visits involving body composition measures, blood testing, strength testing, and a thigh muscle biopsy, participants will go through a 12-week dietary intervention for weight loss. After 12 weeks, this will be followed by the same testing and biopsies that were completed before the intervention.
More18 to 70 years
Inclusion Criteria: Generally healthy men and women aged 18-70 BMI between 30-40 Less than 1 hour of exercise per week Women: may be pre or post menopausal Exclusion Criteria: Type 1 or Type 2 diabetes Thyroid disease History of lung disease Active use of nicotine Severe plasma lipid disorders Taking hormone replacement drugs, blood thinners, or thiazoladinediones Women: Currently going through menopause or peri-menopause Pregnant or breastfeeding History of Polycystic Ovary Syndrome
Outcomes Research
Local
compensation provided
Bryan Bergman, PhD
Protocol Number: 23-0545
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