Tele-Rehabilitation to Improve Mild Traumatic Brain Injury Recovery and Reduce Subsequent Injury Risk

Primary Objective

To examine the efficacy of a smartphone-based virtual neuromuscular/dual-task training (vNDT) intervention to reduce musculoskeletal (MSK) injury and improve outcomes after a recent mild traumatic brain injury (mTBI) in a civilian adult population. This aim will take place at the University of Colorado Anschutz Medical Campus.

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During this study, we will enroll n=48 total subjects who have recently sustained an mTBI. Subjects will be randomized to one of two study groups, followed throughout the duration of the 8-week vNDT intervention period, returned for post-intervention period testing, and then followed via monthly logs for the following year. This study will focus on the assessment of individuals with MTBI between the ages of 18-35. We will review any and all adverse events as a research team to determine the best course of action should an adverse event occur. Recruitment will be conducted by screening for potentially eligible patients at UCHealth Family Medicine and Sports Medicine Clinics through EPIC. Dr. John Spittler is a UCH Family Medicine Clinician who will oversee and support recruitment efforts. Patients who may potentially meet inclusion criteria for the study will be informed of the study, screened for eligibility, and asked if they want to participate at their clinical visit at a UCH Clinic by a member of our research staff. If a member of our research team is unable to be at the potentially eligible patient’s clinical visit, we will send an email (up to 2) or give the patient a phone call (up to 2) to inform them of their potential eligibility to participate in the study and ask if they would like more information. If the patient meets all inclusion criteria, is interested, and wants to participate in the study, we will set a time for the first study visit where we will enroll and consent the patient.




Inclusion criteria: - 18-35 years of age at the time of enrollment - Mild TBI or concussion diagnosis by a physician within 21 days of injury - Confirmed MTBI diagnosis via VA/DOD guidelines at time of enrollment - Participation in regular physical activity prior to injury (confirmed via the Global Physical Activity Questionnaire [GPAQ]) - Access to a smartphone for app download Exclusion criteria: - Moderate or severe TBI - Pre-injury neurological disorder (not including ADD or ADHD) - Abnormal brain imaging findings (if performed as a part of routine care) - Previous TBI (mild/moderate/severe) <6 months prior to enrollment other than the current injury for which they are being seen

Type of Study

Outcomes Research




CU Sports Medicine - Denver
UCHealth Central Park Medical Center

Principal Investigator
Photograph of David Howell,  PhD

David Howell, PhD

Study ID

Protocol Number: 22-1352

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