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Effects of THC on Alcohol Consumption and Brain Function

Primary Objective

We want to test the effects of THC on brain activation and alcohol consumption.

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Description

Alcohol and cannabis are often used together such that their effects overlap. Cannabis edibles (which may contain large doses of THC) have not been well-studied in the laboratory, and it is unclear how such products may impact alcohol consumption patterns. This study will test the effects of orally administered THC on brain function. We will also provide alcohol for consumption in the laboratory.

Main Procedures Involved: Participants will complete 2 laboratory sessions. At one session, they will consume a high-dose THC capsule. At the other session, they will consume an inactive capsule. After the capsule, they will complete an MRI brain scan. After the brain scan, they will be given lunch and a chance to drink alcohol in the laboratory. Once the medication visits are complete, participants will be asked to complete a daily-diary of their alcohol and cannabis use for 14 days.

Duration of Participation: 3-4 weeks

Details
Age
21-40
Eligibility
For the proposed study, we will recruit 50 individuals aged 21-40. -Participants must report drinking at least 5 drinks in one day for males or 4 drinks in one day for females in the past year, -must report using a high dose cannabis, greater or equal to 20mg, at least once in the past year. -Have used alcohol and cannabis at the same time in the past month Exclusion criteria include: • currently seeking treatment for alcohol or cannabis use • pregnancy, trying to become pregnant, breastfeeding; • MRI contraindications (implanted metal, weight > 400 lb, etc.). • Liver disease.
Compensation
$750
Locations

Brain Imaging Center (BIC)
Outpatient CTRC

Principal Investigator
Photograph of Joshua Gowin

Joshua Gowin

Study ID

Protocol Number: 22-1314

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