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Gut microbiome effects on intestinal barrier function in metabolic syndrome in HIV positive men who have sex with men

Primary Objective

This study plans to learn more about metabolic syndrome in people living with HIV (PLWH), specifically men who have sex with men (MSM). Metabolic syndrome is prevalent among PLWH and has been connected to gut health. We plan to investigate the cause of metabolic syndrome in MSM and PLWH.

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Description

The aim of this study is to determine whether intestinal barrier dysfunction is higher in HIV+ MSM with MS compared to without MS and related to deficiency in butyrate-production and/or activity of mucolytic bacteria in the gut microbiome.

Details
Age
Adult
Eligibility
Inclusion Criteria: Men who have sex with men, ages 18-70, those with HIV need to be on ART for 12 months prior to enrollment without detectable virus in the last 6 months. Exclusion Criteria: Current gastrointestinal disease (IBD, celiac, etc.), history of bowel resection, use of high-dose blood thinners in the past 12 months, antibiotic use within 2 months of enrollment, current infection other than HIV.Inclusion Criteria: Men who have sex with men, ages 18-70, those with HIV need to be on ART for 12 months prior to enrollment without detectable virus in the last 6 months. Exclusion Criteria: Current gastrointestinal disease (IBD, celiac, etc.), history of bowel resection, use of high-dose blood thinners in the past 12 months, antibiotic use within 2 months of enrollment, current infection other than HIV.
Locations

Outpatient CTRC
University of Colorado Hospital

Principal Investigator
Photograph of Catherine Lozupone

Catherine Lozupone

Study ID

Protocol Number: 22-1180

Categories

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