Feasibility study of empagliflozin in patients with autosomal dominant polycystic kidney disease

Primary Objective

To determine the tolerability of empagliflozin as a potential treatment for Autosomal Dominant Polycystic Kidney Disease (ADPKD).

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Description

Participation involves taking the study drug empagliflozin or a placebo for 12 months. Blood sample collection, magnetic resonance imaging (MRI) of the kidneys and blood vessel stiffness testing during visits at baseline, 3-month and 12-month to the Renal Research Clinic located at the University of Colorado Anschutz Medical Campus or the University and regular telephone or telemedicine visits. If traveling to the University of Colorado from out-of-state, your airfare and hotel will be arranged and paid for by the study.

Details
Age
Adult
Eligibility
-Age 18-50 years -Diagnosis of autosomal dominant polycystic kidney disease (ADPKD) -GFR 30 - 90 mL/min/1.73 m2 -Rapidly progressing disease based on Mayo imaging class 1C, 1D or 1E -No diabetes or heart failure -Not taking JYNARQUE (tolvaptan) or diuretic medication
Locations

Brain Imaging Center (BIC)
Brain Imaging Center (BIC) - Scan Read
Renal Research Center
University of Colorado Hospital

Principal Investigator
Photograph of Michel Chonchol

Michel Chonchol

Study ID

Protocol Number: 22-0616

More information available at ClinicalTrials.gov: NCT05510115

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