The short-chain fatty acid acetate for improving age-associated arterial dysfunction

Primary Objective

Using a randomized, placebo-controlled, double-blind, parallel group clinical trial, the purpose of this study is to determine the efficacy of oral supplementation with the short-chain fatty acid acetate, a product of gut microbiome-dependent fermentation of dietary soluble fiber, for treating age-associated arterial dysfunction.

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Description

If you join this study, you will participate in Screening, Baseline, Study Period, and End of Study visits over a ~4-month period. These visits will take about 14 hours of your time total. The study visits will take place at the Division of Renal Diseases and Hypertension Clinical Research Unit located in the CU Medicine building on the CU Anschutz Medical Campus.

Details
Age

Adult

Eligibility

Healthy men and women of all racial and ethnic backgrounds.

Inclusion: - Age 50 years or older - Body mass index <40 - Not currently trying to lose or gain a large amount of weight (your weight has not changed more than 11 lbs in the last 3 months) Main exclusions: - Very high levels of regular aerobic exercise - Taking calcium supplements unless you are willing to pause - Previous heart attack or stroke - Chronic kidney disease - Alzheimer's disease or dementia - Cancer within 3 years (except for some skin cancers) - Severe stomach or intestinal diseases - Pregnancy or breast-feeding There are additional inclusion and exclusion criteria that will be assessed in the screening process.

Type of Study

Outcomes Research

Scope

Local

Locations

Anschutz Health and Wellness
Department Specific Free Standing Clinic

Principal Investigator
Photograph of Vienna Brunt,  PhD, MS, BS

Vienna Brunt, PhD, MS, BS

Study ID

Protocol Number: 22-0473

More information available at ClinicalTrials.gov: NCT05424263

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