The short-chain fatty acid acetate for improving age-associated arterial dysfunction

Primary Objective

This study plans to learn more about whether acetate supplementation is an effective means of improving blood vessel function in healthy adults over 50 years of age. Acetate is a substance that is naturally produced by bacteria that live in your gut when you eat fiber. Acetate is considered an investigational drug in this study because it is not currently approved by the FDA for treatment of cardiovascular disease.

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Description

If you join this study, you will participate in Screening, Baseline, Study Period, and End of Study visits over a ~4-month period. These visits will take about 14 hours of your time total. The study visits will take place at the Division of Renal Diseases and Hypertension Clinical Research Unit located in the CU Medicine building on the CU Anschutz Medical Campus.

Details
Age
Adult
Eligibility
Healthy men and women of all racial and ethnic backgrounds.Inclusion: - Age 50 years or older - Body mass index <40 - Not currently trying to lose or gain a large amount of weight (your weight has not changed more than 11 lbs in the last 3 months) Main exclusions: - Very high levels of regular aerobic exercise - Taking calcium supplements unless you are willing to pause - Previous heart attack or stroke - Chronic kidney disease - Alzheimer's disease or dementia - Cancer within 3 years (except for some skin cancers) - Severe stomach or intestinal diseases - Pregnancy or breast-feeding There are additional inclusion and exclusion criteria that will be assessed in the screening process.
Locations

Anschutz Health and Wellness
Department Specific Free Standing Clinic

Principal Investigator
Photograph of Vienna Brunt

Vienna Brunt

Study ID

Protocol Number: 22-0473

More information available at ClinicalTrials.gov: NCT05424263

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