A Phase 1/2, Open-Label, Dose-Escalation, Safety and Tolerability Study of NC318 in Subjects with Advanced or Metastatic Solid Tumors

Study category: Cancer

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- Locally advanced or metastatic disease; locally advanced disease must not be amenable to resection with curative intent. (Phase 2: Non-small cell lung cancer (NSCLC) (adenocarcinoma)). - Subjects who have disease progression after treatment with available therapies that are known to confer clinical benefit, or who are intolerant to treatment, or who refuse standard treatment. (Note: There is no limit to the number of prior treatment regimens). - Willingness to undergo pretreatment and on-treatment tumor biopsies (must allow for adequate sample of tissue from appropriate site). - Known active CNS metastases and/or carcinomatous meningitis. (Subjects with previously treated brain metastases permitted if stable).

Type of Study



University of Colorado Hospital

Principal Investigator
Laura Medina,  MD

Laura Medina, MD

Study ID

Protocol Number: 21-4329

More information available at ClinicalTrials.gov: NCT03665285


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