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Child to Adult

Women with loss of a current singleton pregnancy at < 20 0/7 weeks gestation (documented by ultrasonography or histopathological examination) and two or more prior pregnancy losses. Subject inclusion criteria: Women with loss of a current singleton pregnancy at < 20 0/7 weeks gestation (documented by ultrasonography or histopathological examination) and two or more prior pregnancy losses. Current qualifying pregnancy losses will have undergone a complete clinical evaluation with negative results (or results that do not explain the history of RPL) as follows: • Karyotype and/or microarray for the POC without a pathogenic/likely pathogenic finding(s) • Parental karyotypes (with/without microarray) without a pathogenic/likely pathogenic finding(s) • Pathologic exam of the fetal and placenta (14-20 weeks of gestation) • Lupus anticoagulant test negative • Anticardiolipin IgG < 40 GPL AND IgM < 40 MPL; OR both < 99th percentile • Anti β2 glycoprotein IgG and IgM < 99th percentile • TSH within normal limits (per the local lab’s reference range) • HgbA1C < 6.5 • Hysterosalpingogram or sonohysterogram without uterine anomalies Other family members (such as siblings of the POC, siblings of the biological parents (aunts/uncles of the POC), and grandparents of the POC) may also be considered for inclusion if required for interpretation. These additional family members would only be asked to submit a one-time blood sample. Subject exclusion criteria: The presence of a known etiology for pregnancy loss (e.g., fetal aneuploidy, parental chromosome translocations that are unbalanced or result in an unbalanced translocation in the POC, immunologic disorders, uncontrolled diabetes, uncontrolled thyroid disease, cervical insufficiency, uterine anomalies, and/or or any confirmed genetic condition of either parent that is well-documented to cause pregnancy loss) will be considered exclusion criteria. In addition, individuals using a donor egg(s) or donor sperm will be excluded.