Ovarian Hormone Regulation of Central and Cerebrovascular Hemodynamics

Primary Objective

Did you know women represent 2/3rds of the >5 million individuals living with Alzheimer’s disease? We’d like to know why. Changes in vascular function during menopause may contribute to the increased Alzheimer’s disease risk in women. We are inviting premenopausal (women with regular menstrual periods) and postmenopausal (no menstrual period >12 months) women to participate in a study looking at the effects of estrogen and menopause on vascular function in the brain.

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Description

Inclusion criteria: - Women aged 18-55 years - Non-smoking - Not taking medications to treat high blood pressure or cholesterol

Main Procedures Involved: Benefits for study participants include: Measurement of bone composition and bone density, measurement of blood pressure and blood vessel function, sleep monitoring

Duration of Participation: Premenopausal women: Eight visits ranging from 1-4 hours in duration Postmenopausal women: Three visits ranging from 1-4 hours in duration

Details
Age

18 to 55 years

Eligibility

Generally healthy premenopausal (ages 18-55 years) and postmenopausal women (ages 45-55) years of all races/ethnicities will be enrolled. 1. Premenopausal women will have regular menstrual periods (every 21-35 days). 2. Postmenopausal women will have gone through natural (i.e., non-surgical) menopause with the final menstrual period occurring less than 6 years ago.

Exclusion criteria: 1. Medications to treat high blood pressure, cholesterol, diabetes or heart disease 2. Use of menopausal therapy or oral contraceptives 3. Currently pregnant or intending to become pregnant 4. Smoking

Type of Study

Outcomes Research

Compensation

Compensation provided if eligible

Study ID

Protocol Number: 21-3590

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