The effects of cardiorespiratory fitness, physical activity and sedentary behavior on insulin resistance among breast cancer survivors being treated with anti-estrogen endocrine therapies.

Primary Objective

Specific Aim 1: Examine the association between cardiorespiratory fitness and glucose tolerance/insulin sensitivity in breast cancer survivors treated with endocrine therapies. Specific Aim 2: : Examine associations between sedentary behavior, light, moderate and vigorous physical activity, and glucose tolerance/insulin sensitivity in breast cancer survivors treated with endocrine therapies.

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Details
Age

Adult

Eligibility

Inclusions: 1) Female 2) Diagnosed with breast cancer 3) Age 18-80 years 4) Completed surgery 5) Prescribed an aromatase inhibitor or SERM for at least one year from the time of screening Exclusions: 1) Age <18 or >80 2) Type 1 diabetes 3) Type 2 diabetes 4) Prescribed anti-hyperglycemic medication, insulin, or sulfonylurea 5) Pregnant, breastfeeding, or planning to become pregnant in next 2 months 6) Have absolute contraindications to exercise testing which are: a. Unstable angina b. Recent myocardial infarction, cardiac surgery, or vascular surgery (<3 months) c. Uncontrolled high blood pressure d. Heart failure e. Peripheral artery disease (based on report of symptomatic claudication) f. Hepatic or renal disease g. Severe arthritis or mobility impairment that would interfere with exercise testing

Type of Study

Supportive Care

Resources
Study ID

Protocol Number: 21-3245

More information available at ClinicalTrials.gov: NCT00000000

Categories

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