Assessing diagnostic value of non-invasive FFRCT in coronary care in the emergency department

Primary Objective

The primary objective of the ADVANCE-ED study is to compare decision plans prior to FFRCT with the actual decision made after FFRCT.

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The overall purpose of this study is to help HeartFlow understand if the use of FFRCT in the ED will help physicians with diagnosis and treatment of chest pain.




Age 18 years 2. Clinically stable, symptomatic patients who present to ED/observation unit with suspected CAD 3. CCTA shows at least one ≥40% lesion and no lesions >90% in at least one major epicardial vessel 4. FFRCT processed successfully (if applicable) 5. EKG with no acute ischemic changes 6. Willing to comply with all aspects of the protocol, including adherence to follow up visit 7. Agrees to be included in the study 8. Able to provide written informed consent


Type of Study





Memorial Hospital Central

Study ID

Protocol Number: 22-0025

More information available at NCT05325112

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