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Premature Vascular Aging in Women following an In Vitro Fertilization Pregnancy

Primary Objective

Women who conceive using in vitro fertilization (IVF) may be at increased risk for the development of high blood pressure after pregnancy, a leading risk factor for the development of heart disease. How high blood pressure may develop following a pregnancy conceived through IVF is not known but changes in blood vessel function may be involved. Therefore, the purpose of this research study is to evaluate if women who have had a pregnancy conceived through IVF exhibit increased blood pressure and reduced blood vessel dysfunction compared with women who did not have an IVF pregnancy one-to-five years earlier. To answer this, we will recruit: 1) Women with a prior IVF pregnancy 1-5 years earlier due to male-factor infertility or lack of male partner 2) Women with a healthy pregnancy conceived through natural (unassisted) conception. This study will involve three visits to the CU Anschutz Campus. Compensation is provided.

Study category: Healthy Volunteers

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Description

Main Procedures Involved: Ultrasound of blood vessels, blood draws, 24-hour blood pressure monitoring, sleep monitoring, body composition testing

Details
Age

Adult

Eligibility

Main Inclusion Criteria: Unassisted (natural conception) pregnancy group: 1. Premenopausal women, ages 18-45, in general good health 2. History of a healthy pregnancy 1-5 years earlier 3. No history of cancer, diabetes or heart disease 4. Non-smoking 5. Not currently taking medications to treat high blood pressure or cholesterol 6. Not currently pregnant or wishing to become pregnant in the next 3 months IVF group: 1. Premenopausal women ages 18-45, in general good health 2. Had a pregnancy conceived through in vitro fertilization related to male-factor infertility or no male partner 1-5 years earlier 3. No history of cancer, diabetes or heart disease 4. Non-smoking 5. Not currently taking medications to treat high blood pressure or cholesterol 6. Not currently pregnant or wishing to become pregnant in the next 3 months

Type of Study

Observational

Locations

Outpatient CTRC
University of Colorado Hospital

Principal Investigator
Lyndsey Dubose

Lyndsey Dubose

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