Premature Vascular Aging in Women following an In Vitro Fertilization Pregnancy
The purpose of this research study is to evaluate if women who have had a pregnancy conceived through IVF exhibit increased blood pressure compared with women who did not have an IVF pregnancy one-to-five years earlier. To answer this, we will recruit: 1) Women with a prior IVF pregnancy 1-5 years earlier; 2) Women with a healthy pregnancy conceived through spontaneous (unassisted) conception 1-5 years earlier. Main inclusion/exclusion: 1) Age 18-45 years 2) Non-smoking 3) Not currently taking medications to treat high blood pressure or cholesterol 4) Not currently pregnant or wishing to become pregnant in the next 3 months

Ultrasound of blood vessels, blood draw, 24-hour blood pressure monitoring, body composition and bone mineral density testing
Compensation is provided.
Duration of Participation: Duration of participation: One remote (Zoom visit) and one in-person visit at the University of Colorado Anschutz Medical Campus (4.5 hours in duration)
18 to 45 years
Main Inclusion Criteria: Unassisted (spontaneous conception) pregnancy group: 1. Premenopausal women, ages 18-45, in general good health 2. History of a healthy pregnancy 1-5 years earlier 3. No history of cancer, diabetes or heart disease 4. Non-smoking 5. Not currently taking medications to treat high blood pressure or cholesterol 6. Not currently pregnant or wishing to become pregnant in the next 3 months IVF group: 1. Premenopausal women ages 18-45, in general good health 2. Had a pregnancy conceived through in vitro fertilization1-5 years earlier 3. No history of cancer, diabetes or heart disease 4. Non-smoking 5. Not currently taking medications to treat high blood pressure or cholesterol 6. Not currently pregnant or wishing to become pregnant in the next 3 months
Observational
Compensation is provided, if eligible

Lyndsey Dubose, PhD
Protocol Number: 21-2903
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