Implementation of a novel protocol to measure hypothalamic insulin sensitivity in vivo in human adults

Primary Objective

In this study, we are looking at how the brain responds to insulin through stimulation with a glucose infusion

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Adults age 18-40 with no previous diagnosis of diabetes

BMI greater than 18 and less than 25 kg/m2 OR BMI greater than 27 kg/m2 No diagnosis of diabetes, pre-diabetes, polycystic ovarian syndrome, or cancer of any kind. No diagnosis of severe cognitive disabilities including Down's Syndrome, Autism Spectrum Disorder, or age-related cognitive impairment such as dementia. Not currently taking an anti-psychotic, systemic steroid, insulin sensitizing, insulin replacement therapy, or diet or weight loss medication. No MRI contraindications No use of an intrauterine device (IUD) or progesterone-only hormonal birth control, pregnancy or plans to become pregnant.

Type of Study



Brain Imaging Center (BIC)
Outpatient CTRC
University of Colorado Hospital

Principal Investigator
Photograph of Allison Shapiro,  PhD, MPH

Allison Shapiro, PhD, MPH

Study ID

Protocol Number: 21-2939

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