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Using Oscillometry in Toddler Aerodigestive Patients to Monitor Lung Function Response to Treatment

Study category: Ear, Nose, and Throat

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This study plans to learn more about how a breathing test called oscillometry can help clinical care providers monitor lung health in young children. Oscillometry is an effort-independent lung function test that measures airway resistance and obstruction and lung stiffness during normal breathing. The goal of this project is to study airwave oscillometry (AOS) as a low burden method to obtain non-invasive quantitative assessments of lung function in toddlers age 18 to 47 months old. We expect to show that AOS will provide an easily obtainable metric to assess responses to treatment with respiratory medication, which will benefit the patients and improve health outcomes. In this study, we will 1. Assess different mouthpiece options to help make the test easier to do in young children 2. Obtain AOS measurements in children who are patients in the aerodigestive clinic at Children's Hospital Colorado 3. Compare these measurements to those obtained in children who do not have respiratory conditions If you join the study, your child will be asked to perform a breathing test called oscillometry. To do the test your child will sit in a chair or your lap and breathe normally into a machine. The machine will take measurements to see if the lungs are blocked or if the lungs are either stretchy or stiff. The test will be repeated several times. Your child might be asked to return to the clinic to do the test again in two months. You will be sent a secure website link to complete some questions about your child's health. The breathing test happens during quiet breathing with minimal effort. Your child may feel a slight fluttering sensation in their throat or chest that will go away when the test is over. The mouthpiece or mask that your child will breath in to or the nose clips might feel uncomfortable, but each measurement lasts less than 30 seconds.




1. Age 4-6 years old, or 2. Age 18-47 months old and patient in CHCO Aerodigestive Program, or 3. Age 18-47 months old and no respiratory or aerodigestive conditions

Type of Study



Childrens Hospital Colorado

Principal Investigator
Katharine Smith,  PhD

Katharine Smith, PhD

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