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A Double-blind Randomized Placebo-controlled Parallel Design Multicenter Phase IIIb Study of the Effect of Sodium Zirconium Cyclosilicate (SZC) on Serum Potassium and Serum Bicarbonate in Pateitns with Hyperkalemia and Metabolic Acidosis Associated with Chronic Kidney Disease (NEUTRALIZE)

Study category: Kidney Disease & Hypertension

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This is a 36 day trial with 18 in-person visits comparing the effect of Lokelma vs. placebo on serum potassium and bicarbonate levels.




-18 years or older -CKD stage 3-5 with GFR of 30-59 -Potassium level of 5.1-5.9 -Carbon dioxide level of 16-20

Type of Study



Renal Research Center

Principal Investigator
Jessica Kendrick,  MD

Jessica Kendrick, MD

Study ID

Protocol Number: 21-2470

More information available at NCT04727528

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