Study on the Effect of Sodium Zirconium Cyclosilicate (SZC) on Serum Potassium and Serum Bicarbonate in Patients with High Potassium and Metabolic Acidosis Due to Chronic Kidney Disease (NEUTRALIZE)

Primary Objective

This is a 36 day trial with 8 in-person visits comparing the effect of Lokelma vs. placebo on serum potassium and bicarbonate levels.

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Main Procedures Involved: -blood pressure -blood and urine collection -EKG

Duration of Participation: 36 days




-18 years or older -CKD stage 3-5 with GFR of 30-59 -Potassium level of 5.1-5.9 -Carbon dioxide level of 16-20

Type of Study



Compensation provided

Principal Investigator
Photograph of Jessica Kendrick,  MD

Jessica Kendrick, MD

Study ID

Protocol Number: 21-2470

More information available at NCT04727528

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