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A Phase 4, Randomized, Double-masked, Placebo-controlled, Multicenter Trial to Evaluate the Efficacy and Safety of TEPEZZA? in Treating Patients with Chronic (Inactive) Thyroid Eye Disease


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Procedures include TEPEZZA infusions, blood draws, eye measurements. The trial lasts approximately 8-14 months and includes around 10-18 visits at the clinic.




Initial diagnosis of thyroid eye disease for at least 3 years but less than 8 years Clinical Activity Score of 1 or less At least 3mm of proptosis (eye bulging) from patient's baseline or race/gender norms No previous eye muscle surgery, decompression surgery, or past treatment with TEPEZZA

Type of Study



University of Colorado Hospital

Principal Investigator
Prem Subramanian,  MD, PhD

Prem Subramanian, MD, PhD

Study ID

Protocol Number: 20-2835

More information available at NCT04583735

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