Participate in Research at CU Anschutz

The purpose of this research study is to learn more about the safety and effectiveness of a drug called sargramostim for improving cognitive function and memory in people with Alzheimer’s disease.

The purpose of this research study is to learn more about the safety and effectiveness of a drug called sargramostim for improving cognitive function and memory in people with Alzheimer’s disease. This research study hopes to find out more about how sargramostim works within the body over a longer time period than previously studied

Main Procedures Involved: These visits may include some of the following procedures: 1. Treatment/placebo injections 5X a week during treatment phase 2. Cognitive testing 3. Twice weekly blood draws 4. MRI scans 5. PET Scans 6. Heath questionnaires If determined to be eligible during screening, you will be assigned to one of two arms of the study: 1) receives study medication; 2) receives placebo (a pill or a liquid that looks like medicine but is not real). Health insurance is not needed for this study.

Duration of Participation: Study participation last up to 9-1/2 months. 1. Screening period will last up to 8 weeks 2. Treatment period will last 24 weeks 3. Follow-up visit occurs 45 days after end of treatment