Role of microvascular insulin resistance and cardiorespiratory fitness in diabetes

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Participants will undergo baseline testing of heart and blood vessel function, skeletal muscle function by biopsy, MRIs, and exercise testing. Participants will then complete a 15 week exercise training program, and all testing will be repeated. There are 11 study visits total, and participation is expected to last approximately 6 months.




Age 30-55 BMI 25-40 A1C < 5.7% for controls & <9% for those with diabetes Female participants must be pre-menopausal Non-tobacco users

Participants with diabetes cannot be taking insulin Participants cannot have cardiovascular disease or any physical impairment that would limit exercising on a stationary bicycle

Type of Study

Outcomes Research


CTRC Inpatient
Outpatient CTRC
University of Colorado Hospital

Principal Investigator
Photograph of Judith Regensteiner,  PhD

Judith Regensteiner, PhD

Study ID

Protocol Number: 20-2723

More information available at NCT04791371

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