Participate in Research at CU Anschutz

18 to 64 years

Inclusion criteria: (1) Male and female, (2) BMI: 18.5-40 kg/m2 and weight stable over the previous 6 months, (3) Fasting glucose of 100-125 mg/dL or fasting HbA1c of 5.7-6.4%, or 2h OGTT blood glucose of 140-199mg/dL based on the American Diabetes Association criteria for pre-diabetes. These will be tested during study visits. (4) Less than 150 minutes of moderate-to-vigorous physical activity per week and more than 6 hours of sitting time per day. Exclusion Criteria: (1) Currently pregnant or breastfeeding, or trying to get pregnant, (2) A history of systemic, psychiatric, neurological disease, or drug and alcohol abuse, (3) History of cardiovascular disease or diabetes, uncontrolled hypertension, untreated thyroid disease, renal, hepatic diseases, untreated dyslipidemia or any other medical condition affecting weight or lipid metabolism, (4) Positive for human immunodeficiency virus or hepatitis B or C, (5) Currently taking medications affecting blood sugar, weight, triglycerides, energy intake/energy expenditure, or sleep in the last 3 months, (6) Have abnormal blood chemistry and/or hematology as deemed significant by the study physician, (7) Have a positive urine drug test at screening or upon entry into the laboratory session, (8) Currently a smoker or have been a smoker in the 3 months prior to screening visit, (9) Have donated over 400 mL of blood within 3 months (90 days) of screening for the study, (10) Working night shifts within 1 month of and throughout the study, and (11) Not completing the activity trial days during the screening period to assess willingness and ability of the to complete each of the interventions.

Up to $1350