Clonal hematopoiesis, mild cognitive impairment and kidney function decline.
CH is a common aging-associated biological state that predisposes to subsequent cardiovascular death, however, whether it plays a role in MCI, dementia and kidney disease progression is unknown and understanding this novel risk factor may uncover new ways to reduce the burden of cognitive and kidney function impairment
The study plans to enroll up to 100 people, age 55 -99 years, over the next 5 years. Other criteria for the study include: • a diagnosis of chronic kidney disease (CKD) • GFR 15 - 45 mL/min/1.73 m2 • no history of blood cell cancer, chemotherapy or radiation therapy, diabetes mellitus, active hepatitis C, HIV, bariatric surgery, malabsorption or immobility for more than 1 week in past six months. • no use of drugs that affect bone quality. • Body mass index must be < 35 Kg/m2to participate.
Renal Research Center
University of Colorado Hospital
Michel Chonchol, MD
Protocol Number: 22-0288
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