Pubertal Blockade and Estradiol Effects on Cardiometabolic Health for Transitioning Youth (PUBERTY)

Primary Objective

To evaluate the effects of estrogen on insulin sensitivity and vascular function for transgender youth compared to cisgender controls.

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Description

This study will involve 6 research visits at 3 timepoints for transgender individuals (before starting estrogen and 6 and 12 months after starting estrogen). No medications are given as a part of this study. Cisgender (non-transgender) participants will have 4 visits at two timepoints (baseline and 12 months later). Research visits will include a physical exam, questionnaires, a blood draw, drinking a sugary drink, ultrasounds of the head, neck and arm, riding an exercise bike and a body scan.

Details
Age
Child
Eligibility
Adolescents ages 13-16 years old (transgender females and cisgender males and females)Transgender participants should have 13-16 years old and be planning on clinically starting estrogen (estradiol) within the next 4 months. If they have been on a puberty blocker, should have been on at least 6 months.
Locations

Childrens Hospital Colorado
Outpatient CTRC
University of Colorado Hospital

Principal Investigator
Photograph of Natalie Nokoff

Natalie Nokoff

Study ID

Protocol Number: 19-1226

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