Influenza-Specific Immunity and Responses to Inactivated Influenza Vaccine in Infants: Effect of Maternal Vaccination During Pregnancy

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This study aims to learn more about how babies' immune systems react to the influenza vaccine and if there is any difference between babies whose mothers receive the influenza vaccine, or not, before the baby is born. Study visits will take place during prenatal care and delivery as well as infant follow up at Children's Hospital Colorado.


Child to Adult


We are enrolling healthy pregnant women in their third trimester.

Inclusion Criteria: 1. Pregnant women in the third trimester. Excluded if: 1. Receipt of immunomodulatory medication during pregnancy 2. Chronic Infections (hepatitis B/C, HIV) 3. Multiple gestation pregnancy 4. Pre-Eclampsia 5. Growth restricted fetus 6. Known placental insufficiency 7. Influenza infection in pregnancy 8. Known congenital anomalies of the fetus 9. Preterm delivery 10. Major delivery complications 11. Infection during delivery 12. Severe infant distress at birth 13. Congenital anomalies associated with abnormal immune response

Type of Study



Childrens Hospital Colorado
University of Colorado Hospital

Principal Investigator
Photograph of Adriana Weinberg,  MD

Adriana Weinberg, MD

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