Bicarbonate Administration and Cognitive Function in Midlife and Older Adults with CKD

Primary Objective

This research study is being conducted to examine the effects of oral sodium bicarbonate therapy on blood vessel function in the brain and performance on cognitive tests.

Is this Study for You?

Let's Get Started!


This study is a 52 week intervention with visits at the Renal Research Office on the University of Colorado Anschutz Medical Campus. Visits will include blood pressure checks, blood and urine collection, measurement of brain blood flow, measurement of cognitive function, and assessment of physical function via a questionnaire. Participants will receive information regarding their overall health status; including testing for blood pressure, serum bicarbonate levels and kidney function levels. For more information, please contact Luis Perez at or 303-724-1647.

Main Procedures Involved: Physical exam and medical history Blood draw Blood pressure Cognitive function testing Cerebrovascular function testing

Duration of Participation: You will have approximately 6 study visits where the above procedures will be conducted over 12 months.


50 to 70 years


-Able to provide consent -Age 50-70 years -CKD stage 3b-4 with eGFR of 15-44 -Blood pressure <140/90 prior to randomization

-No history of stroke -No history of dementia -No history of neurologic disease

Type of Study





Compensation provided

Travel Compensation

Travel reimbursement available

Principal Investigator
Photograph of Jessica Kendrick,  MD

Jessica Kendrick, MD

Study ID

Protocol Number: 20-1672

Is this Study for You?

Let's Get Started!

Not finding the right Study for you? Join ResearchMatch, a nation-wide registry connecting volunteers and researchers