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Bicarbonate Administration and Cognitive Function in Midlife and Older Adults with CKD

Primary Objective

Study purpose: This research study is being conducted to examine the effects of oral sodium bicarbonate therapy on blood vessel function in the brain and performance on cognitive tests. Study visits will take place at the Renal Research Office on the University of Colorado Anschutz Medical Campus. Participants will receive information regarding their overall health status; including testing for blood pressure, serum bicarbonate levels and kidney function levels. For more information, please contact Luis Perez at or 303-724-1647

Study category: Kidney Disease & Hypertension

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This study is a 52 week intervention with visits at the CU Med Building on the Anschutz Medical Campus. Visits will include blood pressure checks, blood and urine collection, measurement of brain blood flow, measurement of cognitive function, and assessment of physical function via a questionnaire.




-Able to provide consent -Age 50-70 years -CKD stage 3b-4 with eGFR of 15-44 -Blood pressure <140/90 prior to randomization

-No history of stroke -No history of dementia -No history of neurologic disease

Type of Study





Renal Research Center

Principal Investigator
Jessica Kendrick,  MD

Jessica Kendrick, MD

Study ID

Protocol Number: 20-1672

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