A Phase 1, Multicenter, Open-Label, Dose-Escalation and Expansion, Safety, Pharmacokinetic, Pharmacodynamic, and Clinical Activity Study of Intravenously Administered IO-202 and IO-202 + Azacitidine ? Venetoclax in Acute Myeloid Leukemia (AML) Patients with Monocytic Differentiation and in Chronic Myelomonocytic Leukemia (CMML) Patients (IO-202-CL-001)

Primary Objective

To assess safety and tolerability at increasing dose levels of IO-202 in successive cohorts of participants with relapsed or refractory monocytic AML and CMML in order to estimate the MTD or maximum administered dose (MAD) and select the recommended Phase 2 dose (RP2D)

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Type of Study



Outpatient CTRC
Pathology - SOM
University of Colorado Hospital

Principal Investigator
Photograph of Daniel Pollyea,  MD, MS

Daniel Pollyea, MD, MS

Study ID

Protocol Number: 20-1388

More information available at ClinicalTrials.gov: NCT04372433


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