Research Studies

Males and females must be 18-75 years of age, and have ISN/RPS Class III or IV proliferative LN as evidenced be renal biopsy performed in the 6 months prior to screening or during screening. Patients must exhibit significant proteinuria as evidenced by a UPCR greater than or equal to 1, based on a 24-hour urine collection during screening.

Inclusion: --SLE according to the 2019 European League Against Rheumatism/American College of Rheumatology (EULAR/ACR) Classification Criteria, which are met by the presence of Class III or IV LN (above) and current or past positive antinuclear antibody (ANA) Positive ANA is defined by ANA at a titer of  1:80 on HEp-2 cells or an equivalent positive ANA test at least once. --Receipt of at least one dose of pulse methylprednisolone IV ( 250 mg) or equivalent for treatment of the current episode of active LN during the 6 months prior to screening or during screening A maximum of 3 g methylprednisolone IV or equivalent during the 4 weeks prior to screening or during screening is allowed. --For women of childbearing potential: agreement to remain abstinent (refrain from heterosexual intercourse) or use contraception, and agreement to refrain from donating eggs. --For men: agreement to remain abstinent (refrain from heterosexual intercourse) or use contraceptive methods, and agreement to refrain from donating sperm. Exclusion: --Pregnant or breastfeeding, or intending to become pregnant during the study or within 18 months after the final dose of obinutuzumab or placebo or within 6 weeks after the final dose of MMF. --Severe renal impairment, as defined by eGFR  30 mL/min/1.73 m2 (as estimated using the CKD-EPI equation) or the need for dialysis or renal transplantation --HIV infection, Tuberculosis (TB) infection, Active infection of any kind. --History of cancer, including solid tumors, hematological malignancies, and carcinoma in situ, within the past 5 years