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Novel Evaluations of Aging and Gender-Affirming Hormone Therapy on Vascular Endothelial Function and Metabolic Profiles in Transgender Men Compared to Age Group-Matched Transgender Women and Cisgender Adults

Primary Objective

This study is examining how gender-affirming hormone therapy affects the health of blood vessels and impacts cardiovascular disease risk in transgender men.

Study category: Diabetes & Hormone Disorders

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Transgender men (i. e., assigned female at birth but identify as male) taking testosterone o Ages 18 to 40 or 50 to 75 years o In good general health o Have been on hormones for at least 1 year o No history of gonadectomy o No history of cancer, diabetes or heart disease o Non-smoker (or quit at least one year ago)

Main Procedures Involved: • Blood tests for hormones, cholesterol, clotting factor and other labs • Blood vessel cell collection • Dietary analysis • Physical activity monitor • Questionnaires • Ultrasound of the blood vessels • Measurements of bone mineral density and body composition • Compensation provided



Pilot - A pilot Study is used to obtain information, and work out the logistics and management, deemed necessary for further Research Studies.

Type of Study





Compensation provided


Anschutz Health and Wellness
Outpatient CTRC
University of Colorado Hospital

Principal Investigator
Sean Iwamoto,  MD

Sean Iwamoto, MD

Study ID

Protocol Number: 19-2323

More information available at NCT04237467

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