Research Studies

Using a within-subjects, double-blind, placebo (PLA)-controlled design, this study proposes to investigate the effects of tolcapone (TOLC) on brain activation associated with cognitive control (response inhibition), selective attention, and alcohol cue-reactivity, alcohol subjective effects, and risky decision-making after consumption of a standard drink among individuals with co-occurring Alcohol Use Disorder (AUD) and Attention-Deficit/Hyperactivity Disorder (ADHD).

This study evaluates the effects of an FDA-approved medication called tolcapone in people who have both Alcohol Use Disorder (AUD) and Attention-Deficit/Hyperactivity Disorder (ADHD). The study involves seven visits over a three to four week period, including an assessment visit and two eight-day medication periods during which participants will be assigned to take, in a double-blinded fashion, both tolcapone and a placebo (three visits during each period). During the study period there will be two fMRI scans and two on-campus alcohol administration sessions. Participants must not be seeking treatment for AUD or ADHD and must not be currently taking any psychotropic medications, including stimulant medications for ADHD.