Effects of puberty and pubertal suppression on insulin sensitivity, metabolic rate and vascular health

Is this Study for You?

Let's Get Started!


This study will involve 4-5 in person visits. There will be screening visit for some patients and then a baseline visit over two days. The first day will involve an IV and drinking a sugary drink with blood draws as well as measuring the resting metabolic rate and answering questionnaires. The second day will involve ultrasounds of the blood vessels, riding an exercise bike and having a body scan. These procedures will be repeated 6 months later.




Youth ages 9-14 years in early puberty who are assigned male at birth

1) Age 9-14 years at the time of enrollment 2) Tanner Stage 2-3 baseline pubertal development 3) For transgender individuals - plan to clinically start a puberty blocker in the next 2 months

Type of Study



Childrens Hospital Colorado
Outpatient CTRC
University of Colorado Hospital

Principal Investigator
Photograph of Natalie Nokoff,  MD

Natalie Nokoff, MD

Study ID

Protocol Number: 19-2109

Is this Study for You?

Let's Get Started!

Not finding the right Study for you? Join ResearchMatch, a nation-wide registry connecting volunteers and researchers