Aim 1: Primary outcome measures include lung function measurements from oscillometry and spirometry, change in oscillometry and spirometry measurements after bronchodilator is given, and results from a Six-Minute Walk test. Aim 2: Primary outcome measures are absolute neutrophil count and C-reactive protein in blood. Secondary outcomes to identify an atopic asthma phenotype include eosinophil count, total IgE, allergen specific IgE, and fractional exhaled nitric oxide. Assessment for nicotine exposure via blood cotinine is additional secondary outcome. Aim 3: Primary outcomes are respiratory symptom and quality of life assessments obtained by questionnaires.
-Children ages 3 to 18 years old -Diagnosis of Down Syndrome/Trisomy 21 or mosaicism -Able to walk -Has had a swallow study (videofluoroscopic swallow study or fiberoptic endoscopic evaluation of swalling) performed within the past two years
Pilot - A pilot Study is used to obtain information, and work out the logistics and management, deemed necessary for further Research Studies.
Childrens Hospital Colorado
Protocol Number: 19-2092
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