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MEASURES OF PULMONARY MORBIDITY IN CHILDREN WITH DOWN SYNDROME

Primary Objective

Aim 1: Primary outcome measures include lung function measurements from oscillometry and spirometry, change in oscillometry and spirometry measurements after bronchodilator is given, and results from a Six-Minute Walk test. Aim 2: Primary outcome measures are absolute neutrophil count and C-reactive protein in blood. Secondary outcomes to identify an atopic asthma phenotype include eosinophil count, total IgE, allergen specific IgE, and fractional exhaled nitric oxide. Assessment for nicotine exposure via blood cotinine is additional secondary outcome. Aim 3: Primary outcomes are respiratory symptom and quality of life assessments obtained by questionnaires.

Study

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Details
Age

Child

Phase

Pilot - A pilot Study is used to obtain information, and work out the logistics and management, deemed necessary for further Research Studies.

Type of Study

Outcomes Research

Scope

Local

Location

Childrens Hospital Colorado

Principal Investigator
Emily Deboer

Emily Deboer

Study ID

Protocol Number: 19-2092

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