Research on Computer Training to Help With Mood in Adolescents

Primary Objective

Hostile interpretation bias may be a feature of severe, chronic irritability in children, one of the most common psychiatric symptoms of childhood. Interpretation bias training (IBT) is a computer-based training program that may reduce irritability in youths. This trial lays the groundwork for a test IBT on irritability.

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This study plans to learn more about Interpretation Bias Training (IBT) in adolescents who are seeking outpatient mental health treatment. It uses a computer to show adolescents with irritability pictures of face emotions. The goal of this study is to test whether the training program that targets hostile emotional responses will be successful at treating irritability.

Main Procedures Involved: • Participate in two study visits and an online assessment • Complete interviews, forms, and one 25-minute session of emotion training • Some may train with brain imagining in a magnetic resonance imager (MRI)

Duration of Participation: The entire time required for the study is up to 6 hours over two study visits and an online assessment that is completed remotely after the computer training. All study procedures occur within a two week period.


13 to 17 years


Inclusion Criteria: Adolescents ages 13 to 17 years in mental health treatment, with at least: * mild, clinically significant irritability, and * typical intellectual functioning (IQ>80)

Exclusion Criteria: Any of the following mental health diagnoses: current post-traumatic stress lifetime bipolar I or II disorder lifetime cyclothymic disorder lifetime psychotic disorder lifetime autism spectrum disorder Major medical problems, including head trauma. MRI-specific safety exclusions for the MRI arms. Clinical instability.

Type of Study

Device Feasibility




Compensation Provided.

Principal Investigator
Photograph of Joel Stoddard,  MD

Joel Stoddard, MD

Study ID

Protocol Number: 17-0464

More information available at NCT03592368

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