Back to Results

APOL1 Long-term Kidney Transplantation Outcomes Network

Primary Objective

To test kidney donors and transplant recipients for forms of the APOL1 gene for purposes of evaluating how the various forms may impact both donors and recipients. To determine whether the presence of APOL1 RRVs in a kidney donor shortens death-censored renal allograft survival. Secondary Objectives: 1. Define whether the presence of APOL1 RRVs in a kidney donor is associated with worse renal function or greater proteinuria after transplantation of the kidney; 2. Define whether the presence of APOL1 RRVs is associated with worse renal outcomes in living kidney donors after nephrectomy, and; 3. (if donor APOL1 RRVs are associated with worse kidney function in recipients of renal allografts) identify modifying factors that increase susceptibility for shortened allograft survival, reduced renal allograft function or greater proteinuria in recipients of kidneys from donors with APOL1 high-risk genotypes. Modifying factors may include cause of death in the deceased donor, ischemia time, type of immunosuppression, graft rejection, viral infection, post-engraftment renal dysfunction, etc.

Study category: Kidney Disease & Hypertension

Is this Study for You?

Let's Get Started!

Description

APOLLO is an observational study designed to assess the impact of RRVs in the APOL1 gene on the functional outcomes of kidneys transplanted from living and deceased donors with recent African ancestry and on the kidney function of living kidney donors with recent African ancestry in a prospective manner. In this protocol, recent African ancestry is broadly defined as African American, Afro-Caribbean, Hispanic black, and African.

Details
Age

Child to Adult

Phase

Not Applicable - Describes studies without FDA-defined phases, including studies of devices or behavioral interventions.

Type of Study

Observational

Scope

National

Location

University of Colorado Hospital

Principal Investigator
Alexander Wiseman,  MD

Alexander Wiseman, MD

Study ID

Protocol Number: 19-0461

More information available at ClinicalTrials.gov: NCT03615235

Is this Study for You?

Let's Get Started!

Not finding the right Study for you? Join ResearchMatch, a nation-wide registry connecting volunteers and researchers