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CROCODILE Study: Control of Renal Oxygenation, COnsumption, mitochondrial Dysfunction, and InsuLin rEsistance


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Diabetic Patients: Ages 18-30 Years Old Antibody + Diagnosis of Type 1 Diabetes for at least 5 years Control Patients: Ages 18-30 Years Old No Diagnosis of Type 1 or Type 2 Diabetes

Detailed Eligibility: All participants: BMI greater than 18.5 and less than 30 kg/m2 Weight less than 350 lbs HbA1c less than 11% Hemoglobin greater than 12 g/dl No recent diagnosis of severe illness Not currently pregnant or nursing No diagnosis of anemia No history of allergy to shellfish or iodine No MRI contraindications


I/II - A combination of phases: (1) Research Studies that focus on the safety of a drug. The goal is to determine the drug's most frequent and serious adverse events and, often, how the drug is broken down and excreted by the body. These studies usually involve a small number of participants; and (2) Research Studies that gather preliminary data on whether a drug works in people who have a certain condition/disease (that is, the drug's effectiveness). For example, participants receiving the drug may be compared to similar participants receiving a different treatment, usually an inactive substance (called a placebo) or a different drug. Safety continues to be evaluated, and short-term adverse events are studied.

Type of Study



Childrens Hospital Colorado
Outpatient CTRC
University of Colorado Hospital

Principal Investigator
Petter Bjornstad

Petter Bjornstad

Study ID

Protocol Number: 19-1282

More information available at NCT04074668

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