Participate in Research at CU Anschutz

The purpose of this study is to understand the role of semaglutide, with or without metformin, in restoring ovulation in youth and adults (12-35 years old) with polycystic ovary syndrome.

For this study, participants will complete a screening visit to determine eligibility. They will collect 4-months of daily urine to determine rates of ovulation prior to starting semaglutide treatment. They will complete an oral sugar tolerance test (drink a sugary drink) to measure their body's response to sugar and they will start semaglutide treatment (once-week injection) for 10-months. Participants will be seen every two months for safety labs. At month-6 participants will collect 4-months of daily urine again to measure changes in ovulation. At month 10, they will repeat the oral sugar tolerance test.